Tokyo doesn't have a single centre — it has half a dozen. Base near a JR Yamanote line stop; that ring connects almost every neighbourhood you'll visit.
First-timer pick
Shinjuku — biggest transit hub in the world, endless food, walk to Shibuya.
Best neighborhoods
Shinjuku
$$$Walk: Excellent
Neon, salaryman-after-dark, everything-open-late
First-timersNightlifeLate arrivals
Pros
Shinjuku Station = everywhere in Tokyo
Best late-night food
Narita Express direct
Cons
Sensory overload for some
Kabukicho is seedy at night
Nearby: Golden Gai · Shinjuku Gyoen · Tokyo Metropolitan Building views